癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LRIG1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96JA1 |
| Other Accession | Q96JA1 |
| Reactivity | Rat |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 119113 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LRIG1 |
| Epitope Specificity | 1001-1093/1093 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. |
| SUBUNIT | Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | LRIG1 protein is coded by a gene on a chromosome band 3p14.3, a region known to be deleted in various human cancers. It is considered to be a tumour suppressor gene. LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues. Its 143kDa form may be cleaved into 111kDa and 32kDa fragments. The protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor. |
| Gene ID | 26018 |
|---|---|
| Other Names | LIG-1; LIG1; D6Bwg0781e; Img; LRIG1_HUMAN; LRIG1; LRIG1_MOUSE; leucine rich repeats and immunoglobulin like domains 1; ortholog of mouse integral membrane glycoprotein LIG-1; leucine-rich repeat protein LRIG1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LRIG1 {ECO:0000303|PubMed:15282549} |
|---|---|
| Synonyms | LIG1 |
| Function | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Widely expressed.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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