Uridine Phosphorylase 1 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF, E
Primary Accession	P52624
Other Accession	P52624
Host	Rabbit
Clonality	Polyclonal
Calculated MW	34086 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from mouse Uridine Phosphorylase 1
Epitope Specificity	71-170/310
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SIMILARITY	Belongs to the PNP/UDP phosphorylase family.
SUBUNIT	Homodimer.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA

Additional Information
Gene ID	22271
Other Names	UDRPASE; UP; UPASE; UPP; UPP1_HUMAN; UPP1; UPase 1; UrdPase 1; 2.4.2.3; UPP1_MOUSE;
Dilution	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	Upp1 {ECO:0000312\|MGI:MGI:1097668}
Synonyms	Up, Upp
Function	Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:12077348, PubMed:15772079, PubMed:7744869). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (PubMed:12077348, PubMed:7744869).