癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ZNF366 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8N895 |
| Other Accession | Q8N895 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 85107 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZNF366 |
| Epitope Specificity | 501-600/744 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 11 C2H2-type zinc fingers. |
| SUBUNIT | Interacts with ESR1, NRIP1 and CTBP1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ZNF366 is a 744 amino acid nuclear protein that contains eleven C2H2-type zinc fingers and is thought to function in transcriptional regulation. The gene encoding ZNF366 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. |
| Gene ID | 167465 |
|---|---|
| Other Names | DC-SCRIPT; DCSCRIPT; Znf366; ZN366_HUMAN; Dendritic cell-specific transcript protein (DC-SCRIPT); zinc finger protein 366 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ZNF366 {ECO:0000303|PubMed:12234665} |
|---|---|
| Function | Has transcriptional repression activity. Acts as a corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases. |
| Cellular Location | Nucleus |
| Tissue Location | Expressed in immature and mature dendritic cells (DCs). Not detected in other blood cell types |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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