癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Midnolin Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q504T8 |
| Other Accession | Q504T8 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49213 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MIDN |
| Epitope Specificity | 51-150/468 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 ubiquitin-like domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | 该蛋白可能参与中脑神经核仁的相关调节。 |
| Gene ID | 90007 |
|---|---|
| Other Names | Stx; 3000003C15Rik; MIDN_HUMAN; MIDN; Midbrain nucleolar protein; MIDN_MOUSE; midnolin; stuxnet homolog (Drosophila) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MIDN |
|---|---|
| Function | Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. |
| Cellular Location | Nucleus, nucleolus {ECO:0000250|UniProtKB:Q3TPJ7}. Nucleus. Cytoplasm, cytosol. Note=Detected in the nucleus and nucleolus with no expression in the cytoplasm (By similarity). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (PubMed:24187134) {ECO:0000250|UniProtKB:Q3TPJ7, ECO:0000269|PubMed:24187134} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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