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RGS2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P41220 |
| Other Accession | P41220 |
| Reactivity | Rat, Human |
| Predicted | Pig, Mouse, Chicken, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24382 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RGS2 |
| Epitope Specificity | 116-211/211 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 RGS domain. |
| SUBUNIT | Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha). |
| Post-translational modifications | Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq]. |
| Gene ID | 5997 |
|---|---|
| Other Names | G0S8; GOS8; RGS2_HUMAN; RGS2; Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8; RGS2_MOUSE; RGS2_RAT; regulator of G protein signaling 2; regulator of G-protein signalling 2, 24kD; regulator of G-protein signalling 2, 24kDa; regulator of G-protein signaling 2, 24kDa; regulator of G-protein signaling 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RGS2 |
|---|---|
| Synonyms | G0S8 |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320). |
| Cellular Location | [Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus [Isoform 3]: Cell membrane. Cytoplasm Nucleus, nucleolus |
| Tissue Location | Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98425
