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DRAK1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UEE5 |
| Other Accession | Q9UEE5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46558 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DRAK1/STK17A |
| Epitope Specificity | 45-150/414 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.Contains 1 protein kinase domain. |
| Post-translational modifications | Autophosphorylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) is a novel member of the ser/thr protein kinase family, which mediate apoptosis through their catalytic activities. The full-length cDNA encodes a deduced 414-amino acid protein with a molecular mass of 46.56 kD. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. DRAK1 messenger RNA appears to be ubiquitously expressed in human tissues. Overexpression of DRAK1 induces apoptosis. It has been shown in vitro that DRAK1 is capable of autophosphorylation and of phosphorylating the myosin light chain as an exogenous substrate, and that the noncatalytic C terminus is crucial for full kinase activity. |
| Gene ID | 9263 |
|---|---|
| Other Names | DRAK1; RDRAK1; ST17A_HUMAN; STK17A; DAP kinase-related apoptosis-inducing protein kinase 1; 2.7.11.1; ST17A_RABIT; DAP kinase-related apoptosis-inducing protein kinase 1 (rDRAK1); serine/threonine kinase 17a; serine/threonine kinase 17a (apoptosis-inducing); death-associated protein kinase-related 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | STK17A |
|---|---|
| Synonyms | DRAK1 |
| Function | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. |
| Cellular Location | Nucleus. |
| Tissue Location | Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98441
