癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SC11A Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P67812 |
| Other Accession | P67812 |
| Reactivity | Human |
| Predicted | Rat, Orangutan, Mouse, Rabbit, Zebrafish, Dog, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20625 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SC11A |
| Epitope Specificity | 1-100/179 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the peptidase S26B family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012] |
| Gene ID | 23478 |
|---|---|
| Other Names | 1810012E07Rik; SEC11L1; SPC18; SPCS4A; sid2895; 18kDa; Sid2895p; SC11A_HUMAN; SEC11A; Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit (SPase 18 kDa subunit); SEC11 homolog A; SEC11-like protein 1; 3.4.21.89; SC11A_MOUSE; Sid 2895; SC11A_RAT; SEC11 homolog A, signal peptidase complex subunit; SEC11-like 1 (S. cerevisiae); SEC11 homolog A (S. cerevisiae); signal peptidase complex 18 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SEC11A |
|---|---|
| Synonyms | SEC11L1, SPC18, SPCS4A |
| Function | Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N- terminal signal peptides that contain a hydrophobic alpha-helix (h- region) shorter than 18-20 amino acids (PubMed:34388369). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P67811}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P67811} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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