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G protein beta 4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9HAV0 |
| Other Accession | Q9HAV0 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37567 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human G protein beta 4 |
| Epitope Specificity | 51-150/340 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the WD repeat G protein beta family.Contains 7 WD repeats. |
| SUBUNIT | G proteins are composed of 3 units, alpha, beta and gamma. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Guanine nucleotide binding proteins (G proteins) are membrane associated, heterotrimeric proteins composed of three subunits: alpha, beta and gamma. The G protein beta subunit assumes a barrel shaped beta propeller structure containing WD40 repeats preceded by an N terminal alpha helix. The beta subunit forms a stable dimer with the gamma subunit. The alpha subunit only contacts the beta subunit in the dimer, lying on the opposite face from the gamma subunit. G proteins and their receptors (GPCRs) regulate systems as diverse as sensory perception, cell growth and hormonal regulation. |
| Gene ID | 59345 |
|---|---|
| Other Names | CMTD1F; HG2B; 6720453A21Rik; G(beta)4; GBB4_HUMAN; GNB4; Transducin beta chain 4; GBB4_MOUSE; Q3THF3_MOUSE; Q3TY18_MOUSE; Q3U2F9_MOUSE; GBB4_RAT; Q4V8I8_RAT; G protein subunit beta 4; guanine nucleotide binding protein (G protein), beta polypeptide 4; Guanine nucleotide-binding protein subunit beta-4 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GNB4 |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Tissue Location | Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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