癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HAGH Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q16775 |
| Other Accession | Q16775 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33806 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HAGH |
| Epitope Specificity | 221-308/308 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. |
| SUBUNIT | Monomer. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP). Glyoxalase I and Gyloxalase II (also designated hydroxyacyl glutathione hydrolase or HAGH) are members of the Gyloxalase family. The Gyloxalase II enzyme is a thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form reduced glutathione and D-lactic acid. It exists only as a monomer and binds two zinc ions per subunit. Glyoxalase II contains 260 amino acids. It is detected in the mitochondria and cytosol of mammals. Both Glyoxalase I and Gyloxalase II are detected at a higher activity level in breast cancer tissues than with matched unaffected tissues. This suggests that glyoxalase inhibitor drugs may be effective in the treatment of cancer. |
| Gene ID | 3029 |
|---|---|
| Other Names | GLO2; GLO2D; GLX2; GLXII; HAGH1; Glo-2; Rsp29; GLO2_HUMAN; HAGH; Glyoxalase II (Glx II); 3.1.2.6; GLO2_MOUSE; GLO2_RAT; Round spermatid protein RSP29; hydroxyacylglutathione hydrolase; hydroxyacyl glutathione hydrolase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HAGH |
|---|---|
| Synonyms | GLO2, HAGH1 |
| Function | Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. |
| Cellular Location | [Isoform 1]: Mitochondrion matrix |
| Tissue Location | Expressed in liver and kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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