癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MACC1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6ZN28 |
| Other Accession | Q6ZN28 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 96639 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MACC1 |
| Epitope Specificity | 761-852/852 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 SH3 domain. |
| SUBUNIT | Interacts with FASLG. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MACC1 is a key regulator of the hepatocyte growth factor(HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed19098908]).[supplied by OMIM]. |
| Gene ID | 346389 |
|---|---|
| Other Names | 7A5; SH3BP4L; 4732474O15Rik; Gm267; RGD1309838; MACC1_HUMAN; MACC1; SH3 domain-containing protein 7a5; MET transcriptional regulator MACC1; metastasis associated in colon cancer 1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MACC1 |
|---|---|
| Function | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. |
| Cellular Location | Cytoplasm. Nucleus. Note=Mainly found in the cytoplasm in non-metastasizing tumors |
| Tissue Location | Preferentially expressed in metastasizing tumors. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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