癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DSN1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9H410 |
| Other Accession | Q9H410 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40067 Da |
| Physical State | Liquid |
| Immunogen | Recombinant human DSN1 protein |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBUNIT | Component of the MIS12 complex composed of MIS12, DSN1,NSL1 and PMF1. Also interacts with CASC5, CBX3 and CBX5. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a kinetochore protein that functions aspart of the minichromosome instability-12 centromere complex. Theencoded protein is required for proper kinetochore assembly andprogression through the cell cycle. Alternative splicing results inmultiple transcript variants. [provided by RefSeq, Feb 2009]. |
| Gene ID | 79980 |
|---|---|
| Other Names | C20orf172; KNL3; MIS13; dJ469A13.2; hKNL-3; DSN1_HUMAN; DSN1; DSN1 component of MIS12 kinetochore complex; chromosome 20 open reading frame 172; DSN1, MIND kinetochore complex component, homolog (S. cerevisiae); DSN1 homolog, MIS12 kinetochore complex component; kinetochore null 3 homolog (C. elegans) |
| Dilution | IHC-P=1:100-500,IHC-F=1:400-800,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DSN1 |
|---|---|
| Synonyms | C20orf172, MIS13 |
| Function | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore Note=Associated with the kinetochore. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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