癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TBX6 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O95947 |
| Other Accession | O95947 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47045 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from Human TBX6 |
| Epitope Specificity | 241-330/436 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 T-box DNA-binding domain. |
| SUBUNIT | Forms a dimeric complex with DNA (in vitro). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Members of the T-box (Tbx) gene family share a conserved domain that codes for the T-box, a sequence involved in DNA-binding and protein dimerization. The Tbx gene family is largely conserved throughout metazoan evolution, and is implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system. In the mouse, Tbx6 is involved in both the specification and patterning of the somites along the entire length of the embryo. Specifically, Tbx6 is expressed in the primitive streak, tail bud, and presomitic mesoderm and is essential for the specification of posterior paraxial mesoderm. In the absence of Tbx6, posterior somites are replaced by ectopic neural tubes. |
| Gene ID | 6911 |
|---|---|
| Other Names | SCDO5; rv; TBX6_HUMAN; TBX6; T-box protein 6; TBX6_MOUSE; T-box transcription factor 6; T-box 6 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TBX6 |
|---|---|
| Function | T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. |
| Tissue Location | Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98566
