癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPAG6 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O75602 |
| Other Accession | O75602 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 55476 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SPAG6 |
| Epitope Specificity | 233-290/509 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 8 ARM repeats. |
| SUBUNIT | Interacts with SPAG16 and SPAG17 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. |
| Gene ID | 9576 |
|---|---|
| Other Names | CFAP194; CT141; FAP194; Repro-SA-1; pf16; Spag6; Spag6l1; RGD1310892; XELAEV_18030785mg; PF-16; SPAG6_HUMAN; Protein PF16 homolog; Sperm flagellar protein; SPAG6_MOUSE; Axoneme central apparatus protein; sperm associated antigen 6 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SPAG6 |
|---|---|
| Synonyms | PF16 |
| Function | Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9JLI7}. Note=Associated with microtubules Detected on the sperm flagellum (PubMed:10493827). Localizes in the cilium axoneme in a SPEF1-dependent manner (By similarity) {ECO:0000250|UniProtKB:Q9JLI7, ECO:0000269|PubMed:10493827} |
| Tissue Location | Highly expressed in testis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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