癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FBXO11 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q86XK2 |
| Other Accession | Q86XK2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 103585 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FBXO11 |
| Epitope Specificity | 65-160/927 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 F-box domain. Contains 19 PbH1 repeats. Contains 1 UBR-type zinc finger. |
| SUBUNIT | Component of the probable SCF(FBXWO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with TP53. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for proteasomal degradation. FBXO11 (F-box only protein 11), also known as VIT1 (Vitiligo-associated protein 1), is a 927 amino acid nuclear protein that contains one UBR-type zinc finger, one F-box domain and 19 PbH1 repeats. Involved in protein ubiquitination, FBXO11 functions as a substrate recognition component of the SCF complex and is thought to bind to and inhibit the transcriptional activity of p53. Reduced expression of FBXO11 is associated with vitiligo, a disease characterized by progressive skin depigmentation. Multiple isoforms of FBXO11 exist due to alternative splicing events. |
| Gene ID | 80204 |
|---|---|
| Other Names | FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1; Jf; FBX11_HUMAN; FBXO11; Protein arginine N-methyltransferase 9; Vitiligo-associated protein 1 (VIT-1); FBX11_MOUSE; FBX11_RAT; F-box protein 11; F-box only protein 11; ubiquitin protein ligase E3 component n-recognin 6 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FBXO11 {ECO:0000303|PubMed:25827072, ECO:0000312|HGNC:HGNC:13590} |
|---|---|
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:17098746, PubMed:22113614, PubMed:23478441, PubMed:23478445, PubMed:23892434, PubMed:24613396, PubMed:24968003, PubMed:25827072, PubMed:29059170). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B- cells terminal differentiation toward memory B-cells and plasma cells (PubMed:22113614). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit (PubMed:23478441, PubMed:23478445). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072, PubMed:29059170). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (PubMed:17098746). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (PubMed:33156908). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (PubMed:36897010). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010). |
| Cellular Location | Nucleus. Chromosome |
| Tissue Location | Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP98622
