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ADRA1A Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P97718 |
| Other Accession | P97718 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51744 Da |
| Physical State | Lyophilized or Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse Alpha-1A adrenergic receptor |
| Epitope Specificity | 371-466/466 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. |
| SUBUNIT | Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. |
| Post-translational modifications | C-terminal Ser or Thr residues may be phosphorylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]. |
| Gene ID | 11549 |
|---|---|
| Other Names | ADRA1C; ADRA1L1; ALPHA1AAR; ADA1A_HUMAN; ADRA1A; Alpha-1A adrenoreceptor (Alpha-1A adrenoceptor); Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; ADA1A_MOUSE; ADA1A_RAT; adrenoceptor alpha 1A; adrenergic, alpha-1A-, receptor |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Adra1a {ECO:0000312|MGI:MGI:104773} |
|---|---|
| Synonyms | Adra1c |
| Function | Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1A binds the catecholamine ligands norepinephrine and epinephrine (By similarity). Can also couple to G(14) protein (By similarity). Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1A interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy (By similarity). Additionally, functions as a vasopressor in resistance arteries and plays a role in maintaining normal arterial blood pressure (PubMed:12093905). |
| Cellular Location | Nucleus membrane {ECO:0000250|UniProtKB:P35348}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P35348}; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:P35348}. Membrane, caveola {ECO:0000250|UniProtKB:P35348}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. Colocalizes with CAVIN4 and CAV3 at the plasma membrane and partly within the cytoplasm in cardiomyocytes. {ECO:0000250|UniProtKB:P35348} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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