CD16B mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF
Reactivity	Human
Clonality	Monoclonal
Calculated MW	26 KDa
Physical State	Liquid
Immunogen	Recombinant human Fc gamma RIIIB / CD16b (NA2) Protein
Epitope Specificity	17-200/233
Isotype	IgG
Purity	affinity purified by Protein A
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]

Additional Information
Gene ID	2215
Other Names	CD16; CD16-I; CD16A; CD16b; FCG3; FCGR3; FCGR3A; FCR-10; FCRIII; FCRIIIb; FCG3B_HUMAN; FCGR3B; Fc-gamma RIII-beta (CD16-I \| Fc-gamma RIII \| Fc-gamma RIIIb \| FcRIII \| FcRIIIb); IgG Fc receptor III-1; IGFR3; Fc gamma receptor IIIb; Fc fragment of IgG, low affinity IIIb, receptor for (CD16); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc fragment of IgG receptor IIIb; human neutrophil antigen 1
Dilution	IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Name	CD16B mAb
Function	Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.