癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IRGQ Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8WZA9 |
| Other Accession | Q8WZA9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 62717 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human IRGQ |
| Epitope Specificity | 501-600/623 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. {ECO:0000305}. Contains 1 IRG-type G (guanine nucleotide-binding) domain. {ECO:0000305}. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The function of this gene is not yet known. |
| Gene ID | 126298 |
|---|---|
| Other Names | FKSG27; IRGQ1; IRGQ_HUMAN; IRGQ; immunity related GTPase Q; immunity-related GTPase family, Q1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IRGQ {ECO:0000303|PubMed:39481378, ECO:0000312|HGNC:HGNC:24868} |
|---|---|
| Function | Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (PubMed:39481378). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (PubMed:39481378). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (PubMed:39481378). |
| Cellular Location | Lysosome. Cytoplasmic vesicle, autophagosome |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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