癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PHLDA1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8WV24 |
| Other Accession | Q8WV24 |
| Reactivity | Rat, Mouse |
| Predicted | Human, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45016 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PHLDA1 |
| Epitope Specificity | 251-360/401 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 PH domain. |
| SUBUNIT | Interacts with RPL14, EIF3S7 and PABPC4. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PHLDA1 is involved in regulation of apoptosis induced by signaling of T cell receptor in murine lympocytes. As any potent regulator with pleiotropic effects related to its overexpression, PHLDA attracts attention in both cell biology research and human tissue pathology. |
| Gene ID | 22822 |
|---|---|
| Other Names | DT1P1B11; PHRIP; TDAG51; PHLA1_HUMAN; PHLDA1; Apoptosis-associated nuclear protein; Proline- and glutamine-rich protein (PQ-rich protein | PQR protein); Proline- and histidine-rich protein; T-cell death-associated gene 51 protein; pleckstrin homology like domain family A member 1; pleckstrin homology-like domain, family A, member 1; T-cell death-associated gene 51; proline-histidine rich protein |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PHLDA1 |
|---|---|
| Synonyms | PHRIP, TDAG51 |
| Function | Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles. |
| Tissue Location | Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98742
