癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OASL/TRIP14 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q15646 |
| Other Accession | Q15646 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59226 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human OASL/TRIP14 |
| Epitope Specificity | 141-240/514 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the 2-5A synthase family. Contains 2 ubiquitin-like domains. |
| SUBUNIT | Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 8638 |
|---|---|
| Other Names | OASL1; OASLd; TRIP-14; TRIP14; p59 OASL; p59-OASL; p59OASL; M1204; Mmu-OASL; Oasl; OASL_HUMAN; 2'-5'-OAS-related protein (2'-5'-OAS-RP); 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14 (TR-interacting protein 14 | TRIP-14); p59 OASL (p59OASL); OASL1_MOUSE; 2', 5'-oligoadenylate synthetase-like 9; oasl9; OASL2_MOUSE; Oasl2; 54 kDa 2'-5'-oligoadenylate synthase-like protein (p54 OASL); 2.7.7.84; OASL1_RAT; OASL2_RAT; 2'-5'-oligoadenylate synthetase like |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OASL |
|---|---|
| Synonyms | TRIP14 |
| Function | Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. |
| Cellular Location | [Isoform p56]: Nucleus, nucleolus. Cytoplasm. |
| Tissue Location | Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98771
