癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CKAP4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q07065 |
| Other Accession | Q07065 |
| Reactivity | Rat, Human |
| Predicted | Pig, Mouse, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 66022 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CKAP4 |
| Epitope Specificity | 525-602/602 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Post-translational modifications | Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization.Increased phosphorylation during mitosis prevents binding to microtubules. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CKAP4 is a substrate of DHHC2, a putative tumor suppressor. CK MNF116 and CKAP4 were useful in identifying squamous cell carcinomas with single cell infiltration. These results suggest a role for CKAP4 in tumor. |
| Gene ID | 10970 |
|---|---|
| Other Names | CLIMP-63; CLIMP63; ERGIC-63; p63; 5630400A09Rik; CKAP4_HUMAN; CKAP4; 63-kDa cytoskeleton-linking membrane protein (Climp-63 | p63); CKAP4_MOUSE; cytoskeleton associated protein 4; cytoskeleton-associated protein 4 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CKAP4 |
|---|---|
| Function | Mediates the anchoring of the endoplasmic reticulum to microtubules. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region Note=Translocates to the perinuclear region upon APF-stimulation |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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