癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HSPA4L Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O95757 |
| Other Accession | O95757 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Rabbit, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 94512 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HSPA4L |
| Epitope Specificity | 101-200/839 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the heat shock protein 70 family. |
| SUBUNIT | Homodimer (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, which include the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the low molecular weight HSPs, the immunophilins and the HSP 110 family. The HSP 110 family (also known as the HSP 105 family) is composed of HSP 105, Apg-1 and Apg-2. Apg-1, also known as HSPA4L (heat shock 70 kDa protein 4-like) or Osp94 (osmotic stress protein 94), is an 839 amino acid protein that possesses chaperone activity in vitro, where it inhibits aggregation of citrate synthase. A homodimer, Apg-1 subcellularly localizes to cytoplasm and nucleus, and may translocate to nucleus after heat shock. |
| Gene ID | 22824 |
|---|---|
| Other Names | APG-1; APG1; HSPH3; Osp94; 94kDa; HS74L_HUMAN; HSPA4L; Heat shock 70-related protein APG-1; Heat shock protein family H member 3; Heat-shock protein family A member 4-like protein (HSPA4-like protein); Osmotic stress protein 94; HS74L_MOUSE; Hsp4l; HS74L_RAT; heat shock protein family A (Hsp70) member 4 like; heat shock 70kDa protein 4-like |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HSPA4L |
|---|---|
| Synonyms | APG1, HSPH3, OSP94 |
| Function | Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. |
| Cellular Location | Cytoplasm. Nucleus. Note=May translocate to the nucleus after heat shock. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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