癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Ube2L6 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O14933 |
| Other Accession | O14933 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17769 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Ube2L6 |
| Epitope Specificity | 21-120/153 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the ubiquitin-conjugating enzyme family. |
| SUBUNIT | Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated). |
| Post-translational modifications | ISGylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells, either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. Ubiquitin conjugating enzyme 8 (UBC8) is an E2 enzyme involved in the ubiquitin pathway for protein degradation. Like other E2 enzymes, UBC8 forms a thioester bond with ubiquitin in an E1-dependent manner. UBC8 binds to the human homolog of Drosophila ariadne (HHARI) and UBC7-associated protein (H7-AP1) as well as double ring-finger protein (Dorfin). UBC8 is enriched in the central nervous system and interacts with Parkin, a RING-finger-containing protein implicated in the pathogenesis of familial Parkinson’s disease. Parkin shares sequence homology with other UBC8 binding proteins such as HHARI and H7-AP1. |
| Gene ID | 9246 |
|---|---|
| Other Names | RIG-B; UBCH8; UB2L6_HUMAN; UBE2L6; E2 ubiquitin-conjugating enzyme L6; Retinoic acid-induced gene B protein (RIG-B); Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6; 2.3.2.23; ubiquitin conjugating enzyme E2 L6; ubiquitin-conjugating enzyme E2L 6 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | UBE2L6 |
|---|---|
| Synonyms | UBCH8 |
| Function | Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins (PubMed:15131269, PubMed:16428300). Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 (PubMed:16427630). Promotes ubiquitination and subsequent proteasomal degradation of FLT3 (PubMed:20508617). |
| Tissue Location | Present in natural killer cells (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98811
