癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IL-1 delta/IL36RN Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UBH0 |
| Other Accession | Q9UBH0 |
| Predicted | Rat, Human, Mouse, Rabbit, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16962 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human IL-1 delta/IL36RN |
| Epitope Specificity | 51-130/155 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the IL-1 family. |
| DISEASE | Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
| Gene ID | 26525 |
|---|---|
| Other Names | I36RA_HUMAN; IL36RN; IL-36Ra; FIL1 delta; IL-1-related protein 3 (IL-1RP3); Interleukin-1 HY1 (IL-1HY1); Interleukin-1 delta (IL-1 delta); Interleukin-1 family member 5 (IL-1F5); Interleukin-1 receptor antagonist homolog 1 (IL-1ra homolog 1); Interleukin-1-like protein 1 (IL-1L1); FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; I36RA_MOUSE; Interleukin-1 homolog 3 (IL-1H3); Il1h3; interleukin 36 receptor antagonist; interleukin 1 family, member 5 (delta); family of interleukin 1-delta; interleukin-1 receptor antagonist homolog 1; interleukin-1 HY1; IL-1 related protein 3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IL36RN (HGNC:15561) |
|---|---|
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti- inflammatory signaling pathway by recruiting SIGIRR. |
| Cellular Location | Cytoplasm. Secreted. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. |
| Tissue Location | Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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