癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DCP1B Antibody (center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q8IZD4 |
| Reactivity | Human |
| Predicted | Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 67723 Da |
| Antigen Region | 261-290 aa |
| Gene ID | 196513 |
|---|---|
| Other Names | mRNA-decapping enzyme 1B, 3---, DCP1B |
| Target/Specificity | This DCP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids of human DCP1B. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DCP1B Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DCP1B |
|---|---|
| Function | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q9NPI6} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay.
REFERENCES
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Cougot, N., et al. J. Cell Biol. 165(1):31-40(2004)
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