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Synapsin III Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O14994 |
| Other Accession | O14994 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 63303 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Synapsin III |
| Epitope Specificity | 251-350/580 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the synapsin family. |
| SUBUNIT | Interacts with CAPON |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Synapsins are synaptic vesicle-associated phosphoproteins that regulate synaptic vesicle exocytosis and may be involved in synaptogenesis. Evidence suggests that Synapsin I, Synapsin II and Synapsin IIIa are ATP-binding proteins that are regulated by Ca2+ and calmodulin binding. Ca2+ has been shown to stimulate ATP binding to Synapsin I, to have no effect on Synapsin II and to inhibit Synapsin III. Synapsin I and Synapsin II both undergo alternative splicing to produce two forms of each protein, Synapsin la and lb and Synapsin IIa and IIb, respectively. Synapsin III gives rise to at least three isoforms: Synapsin IIIa, IIIb and IIIc. Synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking. In cultured mouse hippocampal neurons, synapsin III is expressed early during development, with levels peaking seven days after plating and declining thereafter. Synapsin III is highly concentrated in growth cones. |
| Gene ID | 8224 |
|---|---|
| Other Names | SYN3_HUMAN; SYN3; Synapsin III; SYN3_RAT; Synapsin-3 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SYN3 |
|---|---|
| Function | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles |
| Tissue Location | Neuron specific. Detected predominantly in brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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