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GCNF Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q15406 |
| Other Accession | Q15406 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human, Rabbit, Chicken, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54383 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GCNF |
| Epitope Specificity | 91-190/480 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the nuclear hormone receptor family. NR6 subfamily.Contains 1 nuclear receptor DNA-binding domain. |
| SUBUNIT | Homodimer. Interacts with UIMC1 |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Germ cell nuclear factor (GCNF) is an orphan member of the nuclear receptor gene superfamily that influences neurogenesis and germ cell development. GCNF can homodimerize and bind DNA. GCNF regulates paracrine interaction between the oocyte and somatic cells by regulating the expression of BMP-15 and GDF-9, to affect female fertility. GCNF is present in spermatocytes and round spermatids of adult male mouse testis; northern blot and ribonuclease protection assays have shown GCNF is predominant in the testis. The gene expresses three alternatively spliced transcript variants. |
| Gene ID | 2649 |
|---|---|
| Other Names | CT150; GCNF; GCNF1; NR61; RTR; hGCNF; hRTR; 1700113M01Rik; NCNF; NR6A1_HUMAN; NR6A1; Germ cell nuclear factor (GCNF | hGCNF); Retinoid receptor-related testis-specific receptor (RTR | hRTR); NR6A1_MOUSE; Germ cell nuclear factor (GCNF | mGCNF); Retinoid receptor-related testis-specific receptor (RTR); nuclear receptor subfamily 6 group A member 1; nuclear receptor subfamily 6, group A, member 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NR6A1 |
|---|---|
| Synonyms | GCNF {ECO:0000303|PubMed:26769970} |
| Function | Orphan nuclear receptor that binds to a response element containing the sequence 5'-TCAAGGTCA-3' (PubMed:26769970). Acts as a regulator of embryonic stem cell pluripotency by mediating repression of POU5F1/OCT4: binds to the DR0 element within the POU5F1/OCT4 promoter and inhibits POU5F1/OCT4 expression during embryonic stem cell differentiation (PubMed:26769970). Involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). |
| Cellular Location | Nucleus |
| Tissue Location | Shows highest expression in the germ cells of the adult testis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98907
