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DPP8 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q6V1X1 |
| Other Accession | Q6V1X1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 103358 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DPP8/DPRP1 |
| Epitope Specificity | 301-400/898 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily. |
| SUBUNIT | The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). |
| Post-translational modifications | Acetylation of Lys-138 is observed in liver mitochondria from fasted mice but not from fed mice. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. |
| Gene ID | 54878 |
|---|---|
| Other Names | DP8; DPRP-1; DPRP1; MST097; MSTP097; MSTP135; MSTP141; 2310004I03Rik; 4932434F09Rik; DPP VIII; DPP8_HUMAN; DPP8; Dipeptidyl peptidase IV-related protein 1 (DPRP-1); Dipeptidyl peptidase VIII (DPP VIII); Prolyl dipeptidase DPP8; 3.4.14.5; DPP8_MOUSE; dipeptidyl peptidase 8; dipeptidylpeptidase 8; dipeptidyl-peptidase 8; dipeptidyl peptidase VIII; dipeptidyl peptidase IV-related protein-1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DPP8 {ECO:0000303|PubMed:11012666, ECO:0000312|HGNC:HGNC:16490} |
|---|---|
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). |
| Cellular Location | Cytoplasm |
| Tissue Location | Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98920
