癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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QPRT/QAPRTase Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q15274 |
| Other Accession | Q15274 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30846 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human QPRT/QAPRTase |
| Epitope Specificity | 21-120/297 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Belongs to the nadC/modD family. |
| SUBUNIT | Hexamer formed by 3 homodimers. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Quinolinate phosphoribosyltransferase (QPRTase) is a major enzyme in the catabolism of quinolinate. Quinolinate is an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide, and pyrophosphate. Catabolism of quinolinate is vital due to the quinolinate’s neurotoxicity. Increased levels of quinolinate have been linked to neurodegenerative symptoms associated with meningitis and AIDS. QAPRTase has a seven-stranded alpha/beta-barrel domain which is similar in structure to the eight-stranded alpha/beta-barrel enzymes. The protein possesses a novel fold in comparison to other members of the PRTase family. This fold comprises a structure combining two domains. The structure is part alpha/beta barrel-like domain, and part alpha/beta N-terminal domain. |
| Gene ID | 23475 |
|---|---|
| Other Names | HEL-S-90n; QPRTase; NADC_BOVIN; QPRT; Quinolinate phosphoribosyltransferase [decarboxylating] (QAPRTase | QPRTase); 2.4.2.19; NADC_HUMAN; quinolinate phosphoribosyltransferase; nicotinate-nucleotide pyrophosphorylase (carboxylating) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | QPRT |
|---|---|
| Function | Involved in the catabolism of quinolinic acid (QA). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98941
