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CRMP4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q14195 |
| Other Accession | Q14195 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61963 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CRMP4 |
| Epitope Specificity | 88-135/570 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. |
| SUBUNIT | Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity). |
| Post-translational modifications | Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The collapsin response mediator protein (CRMP) family of five cytosolic phosphoproteins are highly expressed throughout brain development. The functions of CRMPs encompass signal transduction in developmental guidance cues as well as multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, CRMPs remain expressed in structures that retain their capacity for differentiation and plasticity. The expression of CRMPs is altered in neurodegenerative diseases, and these proteins may have a role in the physiopathology of the adult nervous system. |
| Gene ID | 1809 |
|---|---|
| Other Names | CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP; ULIP-1; TUC4; Ulip1; TUC-4b; DPYL3_HUMAN; DPYSL3; Collapsin response mediator protein 4 (CRMP-4); Unc-33-like phosphoprotein 1 (ULIP-1); DPYL3_MOUSE; DPYL3_RAT; TOAD-64/Ulip/CRMP; dihydropyrimidinase like 3; dihydropyrimidinase-like 3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DPYSL3 |
|---|---|
| Synonyms | CRMP4, DRP3, ULIP, ULIP1 |
| Function | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). |
| Cellular Location | Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. |
| Tissue Location | Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98949
