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NCR1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O76036 |
| Other Accession | O76036 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34480 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NCR1 |
| Epitope Specificity | 1-100/304 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the natural cytotoxicity receptor (NCR) family. Contains 2 Ig-like (immunoglobulin-like) domains. |
| SUBUNIT | Interacts with CD247 and FCER1G |
| Post-translational modifications | N-glycosylated. O-glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. |
| Gene ID | 9437 |
|---|---|
| Other Names | CD335; LY94; NK-p46; NKP46; KILR-1; NCTR1_HUMAN; NCR1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein (NK-p46 | NKp46 | hNKp46); NCTR1_MOUSE; Activating receptor 1 (mAR-1); Lymphocyte antigen 94; Natural killer cell p46-related protein (NK-p46 | NKp46 | mNKp46); NCTR1_RAT; Activating receptor 1 (rAR-1); NK receptor KILR-1; NKACTR; Natural killer cell p46-related protein (NK-p46 | NKp46); Ar1; Kilr1; natural cytotoxicity triggering receptor 1; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=2ug/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NCR1 |
|---|---|
| Synonyms | LY94 |
| Function | Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Selectively expressed by both resting and activated NK cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98958
