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ALOX15B Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O15296 |
| Other Accession | O15296 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75857 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human 15 Lipoxygenase 2 |
| Epitope Specificity | 221-320/676 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the lipoxygenase family. Contains 1 lipoxygenase domain. Contains 1 PLAT domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized. Tissue specificity: Expressed in hair, prostate, lung and cornea. |
| Gene ID | 247 |
|---|---|
| Other Names | 15-LOX-2; 15-LOX-B; 8-LOX; 8S-LOX; Alox15b; LX15B_HUMAN; 15-lipoxygenase 2 (15-LOX-2); Arachidonate 15-lipoxygenase B (15-LOX-B); Arachidonate 15-lipoxygenase type II; Linoleate 13-lipoxygenase 15-LOb; ALOX8_MOUSE; Alox8; Arachidonate 8S-lipoxygenase (8-LOX | 8S-LOX); Linoleate 9S-lipoxygenase ALOX8; Q5NCF6_MOUSE; Q5NCF7_MOUSE; LX15B_RAT; arachidonate 15-lipoxygenase type B; arachidonate 15-lipoxygenase, second type |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ALOX15B (HGNC:434) |
|---|---|
| Function | [Isoform A]: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (Probable) (PubMed:10542053, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:24497644, PubMed:32404334, PubMed:9177185). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (Probable) (PubMed:10625675, PubMed:11956198, PubMed:12704195, PubMed:17493578, PubMed:24282679, PubMed:24497644, PubMed:9177185). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13- hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2- arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:11956198, PubMed:17493578, PubMed:18311922). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti- inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:11839751, PubMed:12704195). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809). |
| Cellular Location | [Isoform A]: Nucleus. Note=Other isoforms are excluded from the nucleus. |
| Tissue Location | Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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