癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Substance P Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P20366 |
| Other Accession | P20366 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15003 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Substance P (RPKPQQFFGLM) |
| Epitope Specificity | 58-68/129 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the tachykinin family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] This anitbody is crose activity with Neurokinin B. |
| Gene ID | 6863 |
|---|---|
| Other Names | Hs.2563; NK2; NKNA; NPK; TAC2; 4930528L02Rik; NK-1; NK1; PPT-A; PPTA; SP; PPTA3; Ppt5fl; RATPPTA3; TAC; TKN1_HUMAN; TAC1; PPT; NKA; TKN1_MOUSE; TKN1_RAT; tachykinin precursor 1; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma); substance K; substance P; neurokinin 1; neurokinin 2; neuromedin L; neurokinin alpha; neuropeptide K; neuropeptide gamma; preprotachykinin; protachykinin |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,Flow-Cyt=1 µg/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TAC1 |
|---|---|
| Synonyms | NKA, NKNA, TAC2 |
| Function | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. [Neurokinin A]: Is a ligand for TACR2, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:35882833). Binding to TACR2 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). |
| Cellular Location | Secreted. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP99015
