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SP140 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse SP140 |
| Epitope Specificity | 201-300/534 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 bromo domain. Contains 1 HSR domain. Contains 1 PHD-type zinc finger. Contains 1 SAND domain. |
| SUBUNIT | Interacts with PIN1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SP140 is an 867 amino acid cytoplasmic and nuclear protein that is highly expressed in spleen and peripheral blood leukocytes. SP140 is a component of the nuclear body that may be involved in trafficking between the nucleus and the cytoplasm. SP140 is induced by interferons and contains a bromo domain, a HSR domain, a PHD-type zinc finger and a SAND domain. It is thought that SP140 may participate in the pathogenesis of acute promyelocytic leukemia and viral infection. SP140 is expressed as three isoforms produced by alternative splicing and are designated isoform LYSp100-A, isoform LYSp100-B and isoform SP140. |
| Other Names | LYSP100; LYSP100-A; LYSP100-B; SP140_HUMAN; SP140; Lymphoid-restricted homolog of Sp100 (LYSp100); Nuclear autoantigen Sp-140; Speckled 140 kDa; SP140 nuclear body protein |
|---|---|
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | SP140 Rabbit pAb |
| Function | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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