癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PYCR1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q922W5 |
| Other Accession | Q922W5 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32373 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse PYCR1 |
| Epitope Specificity | 241-309/309 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the pyrroline-5-carboxylate reductase family. |
| SUBUNIT | Homodecamer; composed of 5 homodimers. |
| DISEASE | The disease is caused by mutations affecting the gene represented in this entry. Disease description:A disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, a general connective tissue weakness, and varying degrees of growth and developmental delay and neurological abnormalities. Patients do not manifest metabolic abnormalities. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| Gene ID | 209027 |
|---|---|
| Other Names | P5CR 1; P5CR1; P5CR1_MOUSE; Pycr1; P5C reductase 1; 1.5.1.2; B2RYR3_RAT; ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222; PRO3; PYCR; pyrroline-5-carboxylate reductase 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Pycr1 {ECO:0000312|MGI:MGI:2384795} |
|---|---|
| Function | Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5- carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in the cellular response to oxidative stress. |
| Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:P32322}. |
| Tissue Location | Highly expressed in osteoblasts and skin. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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