癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TIP30 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9BUP3 |
| Other Accession | Q9BUP3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27049 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TIP30 |
| Epitope Specificity | 142-242/242 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBUNIT | Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus. Binds the activation domain of HIV-1 Tat. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. Tissue specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. |
| Gene ID | 10553 |
|---|---|
| Other Names | CC3; SDR44U1; TIP30; HTAI2_HUMAN; HTATIP2; 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2; HTAI2_MOUSE; HIV-1 Tat interactive protein 2; HIV-1 Tat interactive protein 2, 30 kDa; HIV-1 Tat interactive protein 2, 30kDa; Tat-interacting protein (30kD); short chain dehydrogenase/reductase family 44U, member 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HTATIP2 (HGNC:16637) |
|---|---|
| Function | Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672). |
| Cellular Location | Cytoplasm. |
| Tissue Location | High levels in liver, lung, skeletal muscle, pancreas and placenta (PubMed:9174052). Moderate levels in heart and kidney (PubMed:9174052). Low levels in brain (PubMed:9174052). Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas (PubMed:14695192). Levels are reduced in the heart of patients with hypertrophic cardiomyopathy and failing hearts (PubMed:31468715). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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