癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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CTNNBL1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8WYA6 |
| Other Accession | Q8WYA6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65173 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CTNNBL1/Beta catenin like 1 |
| Epitope Specificity | 381-480/563 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBUNIT | Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. |
| Gene ID | 56259 |
|---|---|
| Other Names | C20orf33; IMD99; NAP; P14L; PP8304; dJ633O20.1; 5730471K09Rik; NYD-SP19; CTBL1_BOVIN; CTNNBL1; Nuclear-associated protein (NAP); p14; CTBL1_HUMAN; Testis development protein NYD-SP19; CTBL1_MOUSE; CTBL1_RAT; catenin beta like 1; chromosome 20 open reading frame 33; catenin, beta like 1; nuclear associated protein |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CTNNBL1 |
|---|---|
| Synonyms | C20orf33 |
| Function | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:32484799). |
| Cellular Location | [Isoform 1]: Nucleus. |
| Tissue Location | Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99064
