癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GRP Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8R1I2 |
| Other Accession | Q8R1I2 |
| Reactivity | Rat |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15659 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse Gastrin Releasing Peptide |
| Epitope Specificity | 24-52/146 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | ngs to the bombesin/neuromedin-B/ranatensin family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]. |
| Gene ID | 225642 |
|---|---|
| Other Names | BN; GRP-10; preproGRP; proGRP; BLP; GRP_HUMAN; GRP; GRP_MOUSE; GRP_PIG; GRP_RAT; |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Grp |
|---|---|
| Function | Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (PubMed:17653196, PubMed:26658875, PubMed:28280205). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (PubMed:34610277). Contributes to the regulation of food intake (PubMed:12176666). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Contributes to the induction of sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P07492}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q863C3}. Cell projection, neuron projection. Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex |
| Tissue Location | Detected in peptidergic dorsal root ganglion neurons (at protein level) (PubMed:17653196). Expressed in several dozen neurons throughout the dorsal retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) as well as in scattered cells in the nucleus tractus solitarius and parabrachial nucleus (at protein level) (PubMed:26855425). Within the RTN/pFRG, expressed in neuronal subpopulations distinct from those expressing Nmb (at protein level) (PubMed:26855425). Expressed in L6 corticothalamic neurons (at protein level) (PubMed:34610277). Strongly expressed in several input areas of the auditory cortex including the lateral amygdala, contralateral auditory cortex, temporal association area, perirhinal cortex and auditory thalamic nuclei (at protein level) (PubMed:34610277). Detected in the suprachiasmatic nucleus in the hypothalamus (PubMed:28280205) Detected in a subset of glutamatergic cells in the cortex (PubMed:34610277). Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus (PubMed:12526815). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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