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A1CF Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9NQ94 |
| Other Accession | Q9NQ94 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65202 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human A1CF |
| Epitope Specificity | 101-200/594 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 3 RRM (RNA recognition motif) domains. |
| SUBUNIT | Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. |
| Gene ID | 29974 |
|---|---|
| Other Names | ACF; ACF64; ACF65; APOBEC1CF; ASP; 1810073H04Rik; 9130016M20Rik; MCM; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; mer; A1cft; Apobec-1; A1CF_HUMAN; A1CF; APOBEC1-stimulating protein; A1CF_MOUSE; A1CF_RAT; APOBEC1 complementation factor |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | A1CF |
|---|---|
| Synonyms | ACF, ASP {ECO:0000312|EMBL:CAB94754.1} |
| Function | Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense- mediated decay. |
| Cellular Location | Nucleus. Endoplasmic reticulum Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. |
| Tissue Location | Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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