癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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NPRC Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P17342 |
| Other Accession | P17342 |
| Reactivity | Human |
| Predicted | Rat, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59808 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NPR-C |
| Epitope Specificity | 301-400/541 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the ANF receptor family. |
| SUBUNIT | Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Natriuretic peptide receptor C does not exhibit guanylate cyclase activity. There seem to be at least three ANP receptors: two with guanylate cyclase activity (ANPA and ANPB) and one (ANPC) which is probably responsible for the clearance of ANP from the circulation without a role in signal transduction. |
| Gene ID | 4883 |
|---|---|
| Other Names | ANP-C; ANPR-C; ANPRC; BOMOS; C5orf23; GUCY2B; NPR-C; NPRC; EF-2; lgj; stri; ANP-CR; ANPRC_BOVIN; NPR3; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C (ANP-C | ANPR-C | NPR-C); ANPRC_HUMAN; ANPRC_MOUSE; ANPRC_RAT; natriuretic peptide receptor 3; chromosome 5 open reading frame 23; atrionatriuretic peptide receptor C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); natriuretic peptide receptor C; guanylate cyclase C |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NPR3 |
|---|---|
| Synonyms | ANPRC, C5orf23, NPRC |
| Function | Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99112
