癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CSRP2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q16527 |
| Other Accession | Q16527 |
| Predicted | Rat, Pig, Human, Mouse, Rabbit, Chicken, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20954 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CSRP2 |
| Epitope Specificity | 101-193/193 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 2 LIM zinc-binding domains. |
| SUBUNIT | Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CRP2 is a 193 amino acid nuclear protein that belongs to the CRP family of LIM domain proteins. Highly expressed in smooth muscle of aorta, CRP2 is thought to have a role in embryonic vascular system development and is downregulated following cell injury or PDGF-B exposure. CRP2 contains two LIM zinc-binding domains and is encoded by a gene that maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders. |
| Gene ID | 1466 |
|---|---|
| Other Names | CSRP2_BOVIN; CSRP2; Cysteine-rich protein 2 (CRP2); CSRP2_HUMAN; LIM domain only protein 5 (LMO-5); Smooth muscle cell LIM protein (SmLIM); LMO5; SMLIM; CSRP2_MOUSE; Double LIM protein 1 (DLP-1); Dlp1; CSRP2_RAT; cysteine and glycine rich protein 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CSRP2 |
|---|---|
| Synonyms | LMO5, SMLIM |
| Function | Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system. |
| Cellular Location | Nucleus. |
| Tissue Location | Highly expressed in the aorta, but not in heart and skeletal muscle |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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