癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PIP5KL1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q5T9C9 |
| Other Accession | Q5T9C9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44572 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PIP5KL1 |
| Epitope Specificity | 101-220/394 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 PIPK domain. |
| SUBUNIT | Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PIPKH, also known as PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase-like 1), is a 394 amino acid phosphoinositide kinase-like protein that contains one PIPK domain. Although PIPKH lacks intrinsic lipid kinase activity, it associates with type I PIPKs and may play a role in localization of PIPK activity. Encoded by a gene that maps to human chromosome 9q34.11, PIPKH localizes to cytoplasm, specifically to large cytoplasmic vesicular structures, and exists as two alternatively spliced isoforms. Highly expressed in brain and testis, PIPKH is also expressed at very low levels in heart, spleen, lung, liver, skeletal muscle and kidney. PIPKH heterodimerizes with other type I phosphatidylinositol-4-phosphate 5-kinases, and may function as a scaffold to localize and regulate kinases to specific cell compartments. Overexpression of PIPKH may suppress cell proliferation and migration in human gastric cancer cells and may also inhibit cervical cancer formation. |
| Gene ID | 138429 |
|---|---|
| Other Names | PIPKH; PI5L1_HUMAN; PIP5KL1; PI(4)P 5-kinase-like protein 1; PtdIns(4)P-5-kinase-like protein 1; 2.7.1.68; phosphatidylinositol-4-phosphate 5-kinase like 1; phosphatidylinositol-4-phosphate 5-kinase-like 1; phosphatidylinositol phosphate kinase homolog |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PIP5KL1 (HGNC:28711) |
|---|---|
| Function | Likely functions as a regulatory or scaffold-like protein that modulates the subcellular localization and activity of type I PI(4)P 5-kinases (PIPKs) (By similarity). Lacks intrinsic lipid kinase activity (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q6U7H8}. Membrane {ECO:0000250|UniProtKB:Q6U7H8} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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