癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
WIPF2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8TF74 |
| Other Accession | Q8TF74 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46289 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human WIPF2 |
| Epitope Specificity | 31-130/440 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the verprolin family. Contains 1 WH2 domain. |
| SUBUNIT | Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interaction was seen with WASF2 and WASF3. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | WIRE, also known as WIPF2 (WAS/WASL interacting protein family, member 2) or WICH, is a 440 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one WH2 domain. Expressed ubiquitously with highest expression in colon, brain, lung and stomach, WIRE functions as an N-WASP-interacting protein that plays an important role in the organization and mobilization of the Actin cytoskeleton. Additionally, WIRE is involved in the formation of cell surface protrusions and may also provide a link between the cytoskeletal machinery and PDGF-B receptors. Multiple alternatively spliced isoforms of WIRE exist and are encoded by a gene that maps to human chromosome 17. |
| Gene ID | 147179 |
|---|---|
| Other Names | WICH; WIRE; WIPF2_HUMAN; WIPF2; WASP-interacting protein-related protein; WIP- and CR16-homologous protein; WIP-related protein; WAS/WASL interacting protein family member 2; WAS/WASL interacting protein family, member 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | WIPF2 |
|---|---|
| Synonyms | WICH, WIRE |
| Function | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. |
| Cellular Location | Cytoplasm, cytoskeleton Note=Localized to stress fibers and bundles of actin filaments |
| Tissue Location | Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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