癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEM119 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q4V9L6 |
| Other Accession | Q4V9L6 |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 29203 Da |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Post-translational modifications | Showing features for signal, chain, glycosylation, modified residue (large scale data), modified residue. |
| Background Descriptions | Involved in positive regulation of bone mineralization; positive regulation of osteoblast differentiation; and positive regulation of osteoblast proliferation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] |
| Gene ID | 338773 |
|---|---|
| Other Names | OBIF; RGD1307573; TM119_HUMAN; TMEM119; Osteoblast induction factor (OBIF); TM119_MOUSE; B2RYL3_RAT; transmembrane protein 119; osteoblast induction factor |
| Dilution | IHC-P=1:50-200,IHC-F=1:50-200,WB=1:500-2000,IF=1:50-200,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TMEM119 |
|---|---|
| Function | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up- regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q8R138}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R138}. Secreted |
| Tissue Location | Expressed in brain microglia (at protein level) (PubMed:26250788). Detected in urine (at protein level) (PubMed:37453717). Elevated expression levels seen in the brain of patients with Alzheimer disease (PubMed:26250788). Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues (PubMed:26250788). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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