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GASC1/KDM4C Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9H3R0 |
| Other Accession | Q9H3R0 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 119982 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KDM4C/GASC1/JMJD2C |
| Epitope Specificity | 201-300/1056 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the JHDM3 histone demethylase family.Contains 1 JmjC domain.Contains 1 JmjN domain.Contains 2 PHD-type zinc fingers.Contains 2 Tudor domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KDM4C/JMJD2C, a jumonji domain containing protein, is a histone demethylase. JMJD2C specifically demethylates Lysine 9 and Lysine 36 residues of Histone H3, thereby playing a central role in regulating histone modifications. |
| Gene ID | 23081 |
|---|---|
| Other Names | GASC1; JHDM3C; JMJD2C; TDRD14C; 2410141F18Rik; KDM4C_HUMAN; KDM4C; Gene amplified in squamous cell carcinoma 1 protein (GASC-1 protein); JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C; [histone H3]-trimethyl-L-lysine(9) demethylase 4C; 1.14.11.66; KIAA0780; KDM4C_MOUSE; lysine demethylase 4C; jumonji domain containing 2C; lysine (K)-specific demethylase 4C; tudor domain containing 14C |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KDM4C |
|---|---|
| Synonyms | GASC1, JHDM3C, JMJD2C, KIAA0780 |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}. |
| Tissue Location | Overexpressed in several esophageal squamous cell carcinomas (ESCs). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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