癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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GRK1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q15835 |
| Other Accession | Q15835 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 63526 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GRK1 |
| Epitope Specificity | 201-300/563 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain. |
| Post-translational modifications | Autophosphorylated. Farnesylation is required for full activity. |
| DISEASE | Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type 2 (CSNBO2) [MIM:613411]. It is non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq] |
| Gene ID | 6011 |
|---|---|
| Other Names | GPRK1; RHOK; RK; GRK1_HUMAN; GRK1; G protein-coupled receptor kinase 1; 2.7.11.14; GRK1_MOUSE; rhodopsin kinase |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GRK1 (HGNC:10013) |
|---|---|
| Synonyms | RHOK |
| Function | Retina-specific kinase involved in the regulation of phototransduction, playing a key role in terminating the light- activated rhodopsin (RHO) signal in rod photoreceptors. Following light activation, it phosphorylates RHO, thereby promoting binding of S- arrestin (SAG) which then blocks transducin-mediated opsin signaling (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:P28327}; Lipid- anchor {ECO:0000250|UniProtKB:P28327}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVL4} Note=Subcellular location is not affected by light or dark conditions {ECO:0000250|UniProtKB:Q9WVL4} |
| Tissue Location | Retinal-specific. Expressed in rods and cones cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP99194
