癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NT5C3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9H0P0 |
| Other Accession | Q9H0P0 |
| Reactivity | Human |
| Predicted | Rat, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37948 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NT5C3 |
| Epitope Specificity | 1-100/336 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| DISEASE | Autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associated with learning difficulties. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012] |
| Gene ID | 51251 |
|---|---|
| Other Names | CNSHA8; NT5C3; P5'N-1; P5N-1; PN-I; POMP; PSN1; UMPH; UMPH1; cN-III; hUMP1; p36; 1600024P05Rik; 2610206B05Rik; 3110004A18Rik; Nt5c3a; Nt5y; PN-1; Umph-1; lupin; 5NT3A_HUMAN; 7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase); Cytosolic 5'-nucleotidase 3; Cytosolic 5'-nucleotidase III (cN-III); Pyrimidine 5'-nucleotidase 1 (P5'N-1 | P5N-1 | PN-I); Uridine 5'-monophosphate hydrolase 1; 3.1.3.5; P5N1; 5NT3A_MOUSE; 5'-nucleotidase, cytosolic IIIA; cytosolic 5'-nucleotidase 3A |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NT5C3A |
|---|---|
| Synonyms | NT5C3, P5N1, UMPH1 |
| Function | Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Isoforms 1, 3 and 4 are expressed in reticulocytes. Isoform 4 is hardly detectable in bone marrow and fetal liver |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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