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DKK2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UBU2 |
| Other Accession | Q9UBU2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28447 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DKK2 |
| Epitope Specificity | 161-259/259 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the dickkopf family. |
| SUBUNIT | Interacts with LRP5 and LRP6. |
| Post-translational modifications | May be proteolytically processed by a furin-like protease. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
| Gene ID | 27123 |
|---|---|
| Other Names | DKK-2; DKK2_HUMAN; DKK2; Dickkopf-2; hDkk-2; DKK2_MOUSE; mDkk-2; dickkopf Wnt signaling pathway inhibitor 2; dickkopf (Xenopus laevis) homolog 2; dickkopf 2 homolog (Xenopus laevis) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DKK2 |
|---|---|
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in heart, brain, skeletal muscle and lung |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99213
