癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Cytokeratin 15 Mouse mAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P19012 |
| Other Accession | P19012 |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 49212 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Cytokeratin 15 |
| Isotype | IgG1, Kappa |
| Purity | affinity purified by Protein A |
| Buffer | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Proclin300. |
| SIMILARITY | Belongs to the intermediate filament family. |
| SUBUNIT | Heterotetramer of two type I and two type II keratins. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq]. |
| Gene ID | 3866 |
|---|---|
| Other Names | CK15; K15; K1CO; Krt1-15; Ka15; K1C15_HUMAN; KRT15; Cytokeratin-15 (CK-15); Keratin-15 (K15); KRTB; K1C15_MOUSE; K1C15_RAT; Type I keratin Ka15; keratin 15; keratin 15, type I; keratin-15, basic; keratin-15, beta; type I cytoskeletal 15; cytokeratin 15 |
| Dilution | IHC-P=1:200-800,IHC-F=1:200-800,IF=1:200-800 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT15 (HGNC:6421) |
|---|---|
| Synonyms | KRTB |
| Function | Structural component of intermediate filaments in the epithelium. Forms heteropolymers with type II keratin KRT5, assembling into keratin intermediate filament network that promotes mechanical resilience of undifferentiated cells, including hair follicle bulge cells, foregut basal progenitors and intestinal crypt cells. Displays an antagonist role with KRT14 in basal epithelial cells, where KRT14 promotes cell differentiation while KRT15 maintains the progenitor state and promotes proliferation and clonogenicity (PubMed:41511042). Promotes the progenitor state in basal keratinocytes by maintaining cytoplasmic YAP1 less effectively than KRT14 due to missing biochemical motifs, thereby allowing higher YAP1 nuclear activity (PubMed:41511042). Also contributes to epithelial cell regeneration after injury. In the absence of KRT14, forms a bona fide, but ultrastructurally distinct keratin filament network with KRT5 (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q61414}. |
| Tissue Location | Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level) Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate. Expressed in basal cells on the airway surface and in the gland ducts in pulmonary bronchus (PubMed:36512409) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99228
