癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HEY2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UBP5 |
| Other Accession | Q9UBP5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35808 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HEY2 |
| Epitope Specificity | 31-130/337 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the HEY family. Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 Orange domain. |
| SUBUNIT | May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate and establishing boundaries of gene expression. Notch signaling activates the Hairy/Enhancer of split (HES) genes, which encode basic helix-loop-helix (bHLH) transcriptional repressors that are critical for directing embryonic patterning and development. The Hairy-related transcription factors (HRTs) comprise a subclass of bHLH proteins that exhibit structural similarity with the HES proteins and include HRT1, HRT2 and HRT3. The HRT family (also designated Hesr, Hey, CHF and Gridlock) contain a bHLH domain, an Orange domain and a novel YRPW domain, which is absent in HRT3. The Hairy-related genes map to human chromosomes 8q21, 6q21 and 1p34.3 for HRT1, HRT2 and HRT3, respectively, and are downstream targets for Notch signaling. HRT1 is expressed in the somitic mesoderm, central nervous system, kidney, heart, nasal epithelium and limb buds in murine embryos as well as in adult tissues. It has altered expression in many breast, lung and kidney tumors. Like HRT1, HRT2 and HRT3 are also expressed in developing somites, heart and nervous system. |
| Gene ID | 23493 |
|---|---|
| Other Names | CHF1; GRIDLOCK; GRL; HERP1; HESR2; HRT2; bHLHb32; HEY2_HUMAN; HEY2; Cardiovascular helix-loop-helix factor 1 (hCHF1); Class B basic helix-loop-helix protein 32 (bHLHb32); HES-related repressor protein 2; Hairy and enhancer of split-related protein 2 (HESR-2); Hairy-related transcription factor 2 (HRT-2 | hHRT2); Protein gridlock homolog; HERP; HEY2_MOUSE; Hairy-related transcription factor 2 (HRT-2 | mHRT2); hes related family bHLH transcription factor with YRPW motif 2; hairy/enhancer-of-split related with YRPW motif 2; hes-related family bHLH transcription factor with YRPW motif 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HEY2 |
|---|---|
| Synonyms | BHLHB32, CHF1, GRL, HERP, HERP1, HRT2 |
| Function | Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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