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FKBP1B Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P68106 |
| Other Accession | P68106 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 11783 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FKBP1B |
| Epitope Specificity | 21-100/108 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Gene ID | 2281 |
|---|---|
| Other Names | FKBP12.6; FKBP1L; OTK4; PKBP1L; PPIase; 12.6kDa; calstabin2; FKB1B_HUMAN; FKBP1B; PPIase FKBP1B; 12.6 kDa FK506-binding protein (12.6 kDa FKBP | FKBP-12.6); FK506-binding protein 1B (FKBP-1B); Immunophilin FKBP12.6; Rotamase; h-FKBP-12; 5.2.1.8; FKBP9; FKB1B_MOUSE; FKBP prolyl isomerase 1B; FK506-binding protein 1B (12.6 kD); FK506 binding protein 1B, 12.6 kDa; FK506 binding protein 1B; calstabin 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FKBP1B (HGNC:3712) |
|---|---|
| Function | Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| Cellular Location | Cytoplasm. Sarcoplasmic reticulum |
| Tissue Location | Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99241
